Vitamin B could reduce dementia’s effects by up to 50 per cent

Tests suggest daily vitamin B supplements can dramatically slow the onset of Alzheimer’s and similar diseases.
Vitamin B could reduce dementia's effects by up to 50 per centResearchers from the University of Oxford have found that taking tablets of three B vitamins every day slows the brain shrinkage that happens with age, causing early signs of dementia such as memory loss.

In a two-year trial, the vitamin supplement delayed the rate of brain atrophy by up to half in a group of elderly people, with a more than 30 per cent reduction overall. Cognitive tests show those with the least shrinkage perform best.

A vitamin pill that curbed the mental decline associated with ageing would have colossal implications. About 1.5 million people in the UK, 14 million in Europe and five million in the US have problems with memory, language or other mental functions known as Mild Cognitive Impairment (MCI), half of whom go on to develop Alzheimer’s or another form of dementia within five years.

Even a slight slowing of this process would have immense human and economic benefits. However, the researchers said it was too soon to recommend elderly people suffering memory lapses should take B vitamin supplements, until further studies had confirmed the benefits and risks.

Large doses of around 300 times the daily recommended intake of B12 and four times the recommended levels of folic acid were used in the trial. The researchers said this meant they acted like a pharmaceutical drug rather than a nutritional supplement and would require further safety tests. They are now seeking funding for another trial.

The best sources of vitamin B are fresh dairy products and meats. The word fresh is key, as the nutritional value of foods can decline when they are frozen, overcooked, or combined with different additives.

Dark-green leafy vegetables such as spinach, arugula, kale, collard greens, chicory, dandelion greens and Swiss chard, are a great source of folic acid. By steaming these vegetables as opposed to frying or simmering, you reap the greatest benefits because their vitamin content remains intact.

The Oxford research, carried out in association with colleagues in Norway, involved 168 people with MCI, half of whom were given daily doses of vitamin B12, B6 and folic acid (B9).

After two years, MRI scans showed the brains of those who had taken the vitamins had shrunk less – by 0.76 per cent a year – than those given placebo (1.08 per cent) – a 31 per cent difference. In the quarter of elderly people who responded best, the reduction in the rate of shrinkage was 53 per cent.

Brain shrinkage is known to occur more rapidly in people with MCI or Alzheimer’s and high levels of the amino acid homocysteine are linked to an increased risk of the conditions. The researchers believe that the B vitamins slowed the brain atrophy seen in MCI and Alzheimer’s by reducing the levels of homocysteine. People with the highest levels of homocysteine in their blood benefited most.

Although the trial was not designed to measure thinking ability, the researchers found that individuals with the lowest rates of shrinkage had the highest mental test scores.

The findings are published in the journal PLoS [Public Library of Science] One.

Professor David Smith of the Department of Pharmacology, Oxford University, and co-leader of the trial, said: “This is a very striking, dramatic result. It is our hope that this simple and safe treatment will delay the development of Alzheimer’s disease in many people who suffer from mild memory problems.

“These are immensely promising results but we do need to do more trials to conclude whether these particular B vitamins can slow or prevent development of Alzheimer’s. So I wouldn’t yet recommend that anyone getting a bit older and beginning to be worried about memory lapses should rush out and buy vitamin B supplements without seeing a doctor.”

Professor Smith said the key question was whether MCI was a mild manifestation of the more extreme Alzheimer’s disease. “Is this a continuum? Are we seeing a disease that begins a long time ago and gets worse and worse? I personally think so.”

The long-term effects of taking big doses of the vitamins were not known, and there was some evidence that high folate intake could be linked to cancer, he said. However, asked if he would try the vitamin treatment if he was diagnosed with MCI he said: “Yes, no hesitation. I would take it.”

Chris Kennard, chair of the Medical Research Council’s Neurosciences and Mental Health Board which co-funded the study, said: “This trial brings us a step closer to unravelling the complex neurobiology of ageing and cognitive decline.”


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